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KMID : 0881720140290020092
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Journal of Food Hygiene and Safety
2014 Volume.29 No. 2 p.92 ~ p.98
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Monitoring of Fake Anti-impotence Drugs
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Kim Beom-Ho
Jeon Jong-Sup
Lee Myung-Jin
Park Eun-Mi
Cho Sang-Hun
Kwon Hye-Jung
Yoon Mi-Hye
Lee Jung-Bok
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Abstract
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The safety of fake anti-impotence drugs (fake Viagra : 26 samples, fake Cialis : 25 samples) distributed in Gyeonggi province was studied by monitoring the concentrations of anti-impotence pharmaceutical ingredient and their analogues. The concentrations of anti-impotence pharmaceutical ingredient 4 specis and their analogues 17 specis were estimated using by HPLC/PDA, LC-MS/MS. The range of concentration of sildenafil in fake viagra was 40~199 mg/tablet, among them the portion of the concentrations of sildenafil over 150 mg/tablet exceeded 65%. 3 cases in tested samples contained sildenafil and tadalafil. The range of concentration of sildenafil in fake cialis was 102~249 mg/tablet, among them the portion of the concentrations of sildenafil over 150 mg/tablet exceeded 88%. One case in tested samples contained demethylhongdenafil (90 mg/tablet). These results indicate that there were many fake anti-impotence drug contained high level of anti-impotence pharmaceutical ingredients, a sustainable monitoring and the blocked distribution of fake anti-impotence drugs recommended.
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KEYWORD
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fake anti-impotence drugs, sildenafil, tadalafil, demethylhongdenafil
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